Metabolism of Inositol Phosphates

The metabolism and function of inositol phosphates.

& Numa, S . (1984) Nature (London) 307, 604608 Olsen, R. W. (1981) J . Neurochem. 37, 1-13 Parker, I . , Sumikawa, K . & Miledi, R. (1985) f roc . R . Soc. London Ser. B 225, 99 ~ 106 Sakmann, B., Methfessel, C., Mishina, M., Takahashi, T., Takai, T., Kurasaki, M., Fukuda, K . & Numa, S . (1985) Nature (London) 382, 538-543 Sigel, E., Stephenson, F. A,, Mamalaki, C. & Barnard, E. A. (1982) J . ...

SnapShot: Inositol Phosphates

Stereoselective synthesis of inositol phosphates

Pseudomonas putia'a oxidation of benzene affords cis-3,5-cyclohexadiene1,2diol (JJ which serves as a novel precursor for the syntheses of several natural products including (+)-pinitol, (+)-condunto1 F, D-(-)-myo-inositol 1,4,5-trisphosphate and Dmyo-inositol 1-phosphate. The versatility of this approach is further demonstrated by the preparation of other functionalised cyclitol derivatives, in...

Inositol and higher inositol phosphates in neural tissues: homeostasis, metabolism and functional significance.

Inositol phospholipids and inositol phosphates mediate well-established functions in signal transduction and in Ca2+ homeostasis in the CNS and non-neural tissues. More recently, there has been renewed interest in other roles that both myo-inositol and its highly phosphorylated forms may play in neural function. We review evidence that myo-inositol serves as a clinically relevant osmolyte in th...

Inositol phosphates in aquatic systems

While there is a considerable body of research on the abundance and behavior of inositol hexakisphosphate in soils, much less is known regarding its behaviour in aquatic systems. The observed physico-chemical behaviour of this organic P species suggests that in marine and freshwaters, it should be complexed and precipitated by major ions such as calcium, magnesium, iron or aluminium, and thus i...